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定位多克隆抗体反应有助筛选HIV疫苗 - 站长搜索
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定位多克隆抗体反应有助筛选HIV疫苗

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2020-03-26 09:46:05 转载来源: 科技日报

研发HIV疫苗时,合理的免疫原设计旨在将抗体反应集中在抗原上易损位点,但往往还是会伴随脱靶效应,将目标对准其他位点。美国加州拉荷亚市斯克里普斯研究所的巴尔泰克·诺加尔等研究人员,使用电子显微镜多克隆表位定位方法,研究了HIV三聚体亚单位疫苗在非人类灵长类动物体内引发的抗体特异性

研发HIV疫苗时,合理的免疫原设计旨在将抗体反应集中在抗原上易损位点,但往往还是会伴随脱靶效应,将目标对准其他位点。美国加州拉荷亚市斯克里普斯研究所的巴尔泰克·诺加尔等研究人员,使用电子显微镜多克隆表位定位方法,研究了HIV三聚体亚单位疫苗在非人类灵长类动物体内引发的抗体特异性。结果发现,注射疫苗后抗原表位多样性会增加。他们还用冷冻电子显微镜对抗体副作用进行了详细的分子描述。该研究将用来对HIV候选疫苗进行临床前筛选

标签: 定位 克隆 抗体 反应 有助 筛选 HIV 疫苗


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